Produktová podpora

Hana Hodoši (Hrutková)
+421 917 709 186 hodosi@ibiotech.sk Všechny kontakty

Cy7 Rabbit anti-Human, Mouse SHC (Tyr427) Polyclonal Antibody, Cy7 Conjugated [IgG]

Výrobca: Bioss Katalógové č .: bs-3412R-Cy7 Aplikácie: Imunofluorescencia Reaktivita: Human, Mouse Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: Cy7 Laser: 750 nm (infračervený) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:

SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1; SHC1

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

100ul
519,20 EUR
s DPH
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