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FITC Rabbit anti-Human, Rat Rb/p105-Rb(Ser780) Polyclonal Antibody, FITC Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-1347R-FITC Aplikácie: Imunofluorescencia, Prietoková cytometria Reaktivita: Human, Rat Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: FITC Laser: 488 nm (modrý) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:RbSer780; OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 including osteosarcoma; Retinoblastoma 1; Retinoblastoma associated protein; Including osteosarcoma; Osteosarcoma; p105-Rb; Rb; RB_HUMAN; Retinoblastoma suspectibility protein; Retinoblastoma-associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene.
Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.