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ALEXA FLUOR 350 Rabbit anti-Human, Mouse, Rat PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199) antibody, ALEXA FLUOR 350 Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-3332R-A350 Aplikácie: Imunofluorescencia, Prietoková cytometria Reaktivita: Human, Mouse, Rat Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: AlexaFluor 350 Laser: 355 nm (ultrafialový) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:p85; AGM7; GRB1; IMD36; p85-ALPHA; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha; PIK3R1
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.