ALEXA FLUOR 647 Rabbit anti-Human, Mouse, Rat NHLRC2 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated [IgG]

DKFZp779F115; FLJ20147; FLJ25621; MGC45492; NHL repeat containing 2; Novel NHL repeat domain containing protein; NHLC2_HUMAN.

NHLRC2 (NHL repeat containing 2) is a 726 amino acid protein that contains six NHL repeats and one thioredoxin domain. Existing as two alternatively spliced isoforms, NHLRC2 is encoded by a gene that maps to human chromosome 10q25.3. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman_s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.