ALEXA FLUOR 350 Rabbit anti-Human, Mouse, Rat MYLIP Polyclonal Antibody, ALEXA FLUOR 350 Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-9674R-A350 Aplikácie: Imunofluorescencia Reaktivita: Human, Mouse, Rat Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: AlexaFluor 350 Laser: 355 nm (ultrafialový) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:MIR; IDOL; E3 ubiquitin-protein ligase MYLIP; Inducible degrader of the LDL-receptor; Myosin regulatory light chain interacting protein; MYLIP; BZF1; BM-023; PP5242
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
100ul
519,20 EUR
s DPH