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Unconjugated Rabbit anti-Human, Rat KDM5B Polyclonal Antibody [IgG]
Výrobca: Bioss Katalógové č .: bs-6139R Aplikácie: Western Blot, Imunofluorescencia, Imunohistochémia, Prietoková cytometria, ELISA, ELISPOT Reaktivita: Human, Rat Pôvod: Rabbit Klonalita: Polyclonal Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBBP2H1A; Lysine-specific demethylase 5B; Cancer/testis antigen 31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1; KDM5B; RBBP2H1
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).