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Hana Hodoši (Hrutková)
phone+421 917 709 186 mailhodosi@ibiotech.sk Všechny kontaktyarrow

ALEXA FLUOR 555 Rabbit anti-Human EGFRv3 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated [IgG]

Výrobca: Bioss Katalógové č .: bs-2558R-A555 Aplikácie: Imunofluorescencia, Prietoková cytometria Reaktivita: Human Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: Alexa Fluor 555 Laser: 550 nm (zeleno-žltý) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:

EGFR vIII; EGFRvIII; Epidermal growth factor receptor variant type _; epidermal growth factor receptor isoform a variant; ERBB; HER1; ERBB1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

100ul
519,20 EUR
s DPH
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