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ALEXA FLUOR 647 Rabbit anti-Human, Rat Dnmt3a Polyclonal Antibody, ALEXA FLUOR 647 Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-0497R-A647 Aplikácie: Imunofluorescencia, Prietoková cytometria Reaktivita: Human, Rat Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: AlexaFluor647 Laser: 633 nm (červený) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:TBRS; DNMT3A2; M.HsaIIIA; DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.