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Cy5.5 Rabbit anti-Human DNA Polymerase Kappa/POLK Antibody, Cy5.5 Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-13019R-Cy5.5 Aplikácie: Imunofluorescencia, Prietoková cytometria Reaktivita: Human Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: Cy5 Laser: 633 nm (červený) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:DNA polymerase kappa; DINB protein; Short=DINP; POLK_HUMAN.
DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.