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Hana Hodoši (Hrutková)
+421 917 709 186 hodosi@ibiotech.sk Všechny kontakty

Cy7 Rabbit anti-Human, Mouse, Rat DIS3L Polyclonal Antibody, Cy7 Conjugated [IgG]

Výrobca: Bioss Katalógové č .: bs-9052R-Cy7 Aplikácie: Imunofluorescencia Reaktivita: Human, Mouse, Rat Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: Cy7 Laser: 750 nm (infračervený) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:

DIS3 like exonuclease 1; DIS3 mitotic control homolog S. cerevisiae like; FLJ38088; KIAA1955; MGC4562; DI3L1_HUMAN.

The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3_ to 5_ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3_ regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

100ul
519,20 EUR
s DPH
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