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Hana Hodoši (Hrutková)
+421 917 709 186 hodosi@ibiotech.sk Všechny kontakty

Cy7 Rabbit anti-Human CRTAP Polyclonal Antibody, Cy7 Conjugated [IgG]

Výrobca: Bioss Katalógové č .: bs-12949R-Cy7 Aplikácie: Imunofluorescencia Reaktivita: Human Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: Cy7 Laser: 750 nm (infračervený) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:

Cartilage associated protein; LEPREL3; leprecan-like 3; CASP; CRTAP_HUMAN.

CRTAP is a secreted protein localizing to the extracellular space that plays a role in collagen post-translational modifications, extracellular fibril assembly and intracellular trafficking. CRTAP is widely expressed with predominant expression in articular chondrocytes. It contains a signal peptide and a tetratricopeptide-like helical domain and is essential for normal bone formation. In the endoplasmic reticulum (ER), CRTAP forms a complex with Gros1 and CyPB (cyclophilin B) and is required for the efficient 3-hydroxylation of target prolyl residues in Collagen Type I molecules, the major structural proteins of skin and bone. Mutations in the gene encoding CRTAP can lead to autosomal recessive osteogenesis imperfecta (OI) type 7 and type 2B. OI, also known as brittle bone disease, is characterized by bone fragility and susceptibility to fractures. OI type 7 is a mild form of this disorder, while OI type 2B is a neonatal lethal condition.

100ul
519,20 EUR
s DPH
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