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ALEXA FLUOR 350 Rabbit anti-Human, Rat, Sheep Caspase 8 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-0052R-A350 Aplikácie: Imunofluorescencia, Prietoková cytometria Reaktivita: Human, Rat, Sheep Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: AlexaFluor 350 Laser: 355 nm (ultrafialový) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:MACH; Mch5; FLICE; CASP-8; Caspase-8; Casp8
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP1. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.