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Biotin Rabbit anti-Mouse ASPP2/p53BP2 Polyclonal Antibody, Biotin Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-1283R-Biotin Aplikácie: Western Blot, Imunohistochémia, ELISA, ELISPOT Reaktivita: Mouse Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: Biotin/Purifikovaná Laser: Ostatné Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:BBP; 53BP2; ASPP2; P53BP2; PPP1R13A; Apoptosis-stimulating of p53 protein 2; Bcl2-binding protein; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; p53-binding protein 2; TP53BP2
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.