ALEXA FLUOR 647 Rabbit anti-Mouse, Rat AMPK beta 1 (Ser182) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated [IgG]
Výrobca: Bioss Katalógové č .: bs-3027R-A647 Aplikácie: Imunofluorescencia Reaktivita: Mouse, Rat Pôvod: Rabbit Klonalita: Polyclonal Konjugáty: AlexaFluor647 Laser: 633 nm (červený) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:AMPK; HAMPKb; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb; PRKAB1
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).