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Unconjugated Mouse anti-Human MGMT (4C12) Monoclonal Antibody [IgG1]
Výrobca: Bioss Katalógové č .: bsm-51234M Aplikácie: Western Blot, Imunofluorescencia, Imunohistochémia Reaktivita: Human Pôvod: Mouse Klonalita: Monoclonal Podtrieda: IgG1 Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:Methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.