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Unconjugated Rabbit anti-Human, Mouse, Rat Cytokeratin 4 (2F9) Monoclonal Antibody [IgG]
Výrobca: Bioss Katalógové č .: bsm-52062R Aplikácie: Western Blot, Imunofluorescencia, Imunohistochémia Reaktivita: Human, Mouse, Rat Pôvod: Rabbit Klonalita: Monoclonal Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:Keratin, type II cytoskeletal 4; KRT4
Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.