Unconjugated Rabbit anti-Human, Mouse, Rat VAMP3 (8A3) Monoclonal Antibody [IgG]

Vesicle-associated membrane protein 3; Cellubrevin; Synaptobrevin-3; VAMP-3; CEB; SYB3

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP3 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. VAMP3 is involved in vesicular transport from the late endosomes to the trans-Golgi network.