Unconjugated Rabbit anti-Human, Mouse, Rat SNRPA (2A1) Monoclonal Antibody [IgG]

U1 small nuclear ribonucleoprotein A; U1 snRNP A; U1-A; U1A; SNRPA

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.