Unconjugated Rabbit anti-Human, Mouse, Rat Nectin 2 (3G7) Monoclonal Antibody [IgG]

Nectin-2; Herpes virus entry mediator B; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2; CD112; Herpesvirus entry mediator B; HveB; NECTIN2, HVEB; PRR2; PVRL2

Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3.