Unconjugated Rabbit anti-Human, Mouse, Rat CRMP1 (6C5) Monoclonal Antibody [IgG]

Dihydropyrimidinase-related protein 1; Collapsin response mediator protein 1; Unc-33-like phosphoprotein 3; CRMP-1; ULIP-3; CRMP1; DPYSL1; ULIP3.

Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-1 is also involved in cancer invasion and metastasis. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. CRMP-1 plays a role in axon guidance, invasive growth and cell migration. CRMP-1 may participate in cytokinesis.