Unconjugated Rabbit anti-Human, Mouse, Rat Caspase 2 (2B1) Monoclonal Antibody [IgG]

Caspase-2; Neural precursor cell expressed developmentally down-regulated protein 2; Protease ICH-1; CASP-2; NEDD-2; Caspase-2 subunit p18

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress.