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Unconjugated Rabbit anti-Human, Mouse, Rat BUB3 (24D1) Monoclonal Antibody [IgG]
Výrobca: Bioss Katalógové č .: bsm-54413R Aplikácie: Western Blot, Imunofluorescencia, Imunohistochémia, Prietoková cytometria, Imunoprecipitácia, imunoaglutinácia Reaktivita: Human, Mouse, Rat Pôvod: Rabbit Klonalita: Monoclonal Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:Mitotic checkpoint protein BUB3; BUB3
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
100ul
543,40 EUR
s DPH