Unconjugated Rabbit anti-Human, Mouse, Rat BANF1 (11H3) Monoclonal Antibody [IgG]

Barrier-to-autointegration factor; Breakpoint cluster region protein 1; Barrier-to-autointegration factor N-terminally processed; BANF1; BAF; BCRG1; NGPS; BCRP1;

Barrier-to-autointegration factor (BANF1) binds non-specifically to double stranded DNA, possibly to play a role in tissue- or cell type-specific gene expression by interacting with different homeodomain transcription factors. BANF1 compresses chromatin structure and interacts with the LEM domain of nuclear proteins to play a crucial role in membrane recruitment and chromatin decondensation during nuclear assembly. Additionally, retroviruses like HIV-1 incorporate BANF1 from host cells into preintegration complexes (PICs) to prevent autointegration of retroviral DNA and thereby promote integration of retroviral DNA into the host chromosome.