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Hana Hodoši (Hrutková)
+421 917 709 186 hodosi@ibiotech.sk Všechny kontakty

Unconjugated Rabbit anti-Human, Mouse Perilipin A (6C2) Monoclonal Antibody [IgG]

Výrobca: Bioss Katalógové č .: bsm-52913R Aplikácie: Western Blot, Imunofluorescencia Reaktivita: Human, Mouse Pôvod: Rabbit Klonalita: Monoclonal Konjugáty: PE Laser: 488 nm (modrý) Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:

Perilipin-1, Lipid droplet-associated protein, PLIN1

Perilipins, members of the PAT protein family (named after lipid droplet proteins Perilipin, Adipophilin, and TIP47) are found exclusively at the surface of lipid droplets in adipocytes and steroidogenic cells. They have been suggested to function as regulators of lipolysis and triacylglycerol storage within adipose tissue. Four distinct isoforms ranging from perilipin A (57 kDa) to perilipin D (26 kDa) have been identified and they share an identical amino terminal sequences, and contain 26 consensus protein kinase A (PKA) phosphorylation sites. Perilipin C and D have been detected only in steroidogenic cells. Perilipin A is the most abundant form on the lipid droplets of adipocytes. The phosphorylation of perilipin by PKA, which is accompanied by the phosphorylation and translocation of hormone-sensitive lipase from the cytosol to the lipid droplets, promotes lipolysis. There is evidence for the presence of perilipin A in atheroma plaques suggesting that the protein may be involved in the development of therosclerosis by controlling as in adipocytes the hydrolysis of stored lipids.

100ul
543,40 EUR
s DPH
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