ALEXA FLUOR 350 Rabbit anti-Human, Mouse, Rat IL-10 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated [IgG]

CSIF; TGIF; GVHDS; IL-10; IL10A; Interleukin-10; Cytokine synthesis inhibitory factor; IL10

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. IL-10 Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.